KonFound

Quantify robustness of causal inference

My role: Collaborator (PI: Dr. Kenneth Frank)

Intro

Unmeasured confounding is fundamental to social and health sciences. Even after controlling for the most likely alternative explanations for an inferred effect, there may be some alternative explanation(s) that cannot be ruled out with observed data.

Generally, the first response is to develop the best models that maximally leverage the available data. After that, sensitivity analyses can inform discourse about an inference by quantifying the unobserved conditions necessary to change the inference.

This project advances sensitivity analysis tools so that applied researchers can use such tools to better communicate their findings.

Our approaches could be applied to linear regression, logistic regression, mediation, as well as other research designs.

Tools

Related Publications

2023

  1. How do unobserved confounding mediators and measurement error impact estimated mediation effects and corresponding statistical inferences? Introducing the R package ConMed for sensitivity analysis
    Qinyun LinAmy K. Nuttall, Qian Zhang, and Kenneth A. Frank
    Psychological Methods, Oct 2023
  2. Quantifying the robustness of causal inferences: Sensitivity analysis for pragmatic social science
    Kenneth A. FrankQinyun LinRan Xu, Spiro Maroulis, and Anna Mueller
    Social Science Research, Feb 2023

2022

  1. Response to “three comments on the RIR method”
    Kenneth A. FrankQinyun Lin, Spiro Maroulis, Anna S. Mueller, Ran Xu, Joshua M. Rosenberg, Christopher S. Hayter, Ramy A. Mahmoud, Marynia Kolak, Thomas Dietz, and Lixin Zhang
    Journal of Clinical Epidemiology, Jun 2022

2021

  1. Hypothetical case replacement can be used to quantify the robustness of trial results
    Kenneth A. FrankQinyun Lin, Spiro Maroulis, Anna S. Mueller, Ran Xu, Joshua M. Rosenberg, Christopher S. Hayter, Ramy A. Mahmoud, Marynia Kolak, Thomas Dietz, and Lixin Zhang
    Journal of Clinical Epidemiology, Jun 2021